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| Registros recuperados: 1.286 | |
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| Nusrat,Birjees; Siddiqui,Nadeem; Sahu,Meeta; Naim,Mohd. Javed; Shahar Yar,Mohammad; Ali,Ruhi; Ozair,Alam. |
| A series of N-substituted-3-(napthalen-2-yl)-5-substituted phenyl-4,5-dihydropyrazole-1-carbothioamide derivatives (4a-n) were synthesized with the view of structural requirements of pharmacophore for potential anticonvulsant agents. The synthesized compounds were assayed intraperitoneally (i.p.) and subcutaneously (s.c.) in mice against seizures induced by MES and scPTZ methods, respectively.Neurologic deficit was evaluated by rotarod method. Among the tested compounds, 4g, 4i, 4j and 4n emerged as the most active molecule in the MES model at a dose of 30 mg/kg at 0.5h comparable to standardscarbamazepine and phenytoin. In the scPTZ test,4e and 4l were found to be most active compounds at the lowest dose of 30 mg/kg at 0.5h, in the management of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrazolines; Anticonvulsants; Molecular docking; Neurotoxicity. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100516 |
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| Estrada,Martín Hermógenes; Insuasty,Henry; Cuca,Luis Enrique; Marder,Mariel; Fierro,Angélica; Guerrero,Mario Francisco. |
| This work evaluates the central nervous effects in ICR strain mice of 2-ethylthio-7-methyl-4-(4-methylphenyl)pyrazolo[1,5-a][1,3,5]triazine (MH4b1), a compound obtained by an efficient one-step reaction of S,S-diethyl 4-methylbenzoylimidodithiocarbonate with 5-amino-3-methyl-1H-pyrazole, in order to assess its neuro-pharmacological profile. The tests applied were: maximal electroshock seizure (MES), pentylenetetrazole (PTZ) seizures, forced swimming, plus maze, marble burying, sleeping time, rota-rod and catalepsy. In addition, MH4b1 binding to the benzodiazepine site of the GABA-A receptor and MH4b1 inhibition of monoamine oxidase (MAO) subtypes A and B were evaluated. MH4b1 showed anticonvulsant effects in a dose dependent manner (30-300 mg/kg, p.o.)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrazolo-triazine/anticonvulsant profile; Anticonvulsants/experimental study; Monoamine oxidase/inhibitors. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100007 |
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| Ozbek,Hanefi; Acikara,Ozlem Bahadir; Oz,Burcin Ergene; Ozbilgin,Serkan; Kirmizi,Neriman Ipek; Ozrenk,Bade Cevriye; Tekin,Mehmet; Saltan,Gulcin. |
| In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Onobrychis; Antidiabetic activity; Alloxan; Rutin; Isoquercetin; Phytochemical analysis.. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100504 |
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| Asif,Muhammad; Saleem,Mohammad; Yousaf,Sobia; Saadullah,Malik; Zafar,Memoona; Khan,Rizwan Ullah; Yuchi,Alamgeer. |
| The current study evaluated antidiabetic and antihyperlipidemic activities of aqueous extract of Sigesbeckia orientalis L. (St. Paul’s Wort) (AESO) in an alloxan-induced diabetic rat model. Following OECD guidelines safe doses of AESO were assessed in rats for the main study. Serum/bood glucose, α-amylase, and lipids levels and histopathological evaluations were conducted to assess antidiabetic and associated antihyperlipidemic efficacies of AESO. AESO was found to be safe up to the dose of 2000 mg/kg. Significant (p < 0.05) reduction in glucose and lipids (total cholesterol, triglycerides, low-density lipoproteins) levels was observed in AESO treatment groups. Serum α-amylase, high-density lipoproteins, and total body weight was increased significantly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antidiabetic; Sigesbeckia orientalis L; Alloxan; Antihyperlipidemic; HPLC. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100607 |
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| Birgani,Golshan Arzani; Ahangarpour,Akram; Khorsandi,Layasadat; Moghaddam,Hadi Fathi. |
| ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Betulinic acid; Diabetes; Mouse; Streptozotocin-nicotinamide.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200621 |
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| Vinagre,Anapaula Sommer; Rönnau,Ângela Della'Santa Rubio Origuella; Pereira,Sabrina Francisco; Silveira,Lídia Uliano da; Wiilland,Elenir de Fátima; Suyenaga,Edna Sayuri. |
| The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Campomanesia xanthocarpa/pharmacognosy; Diabetes Mellitus/experimental study; Hypoglycemic plant; Histology; Carbohydrate/metabolism; Lipid/metabolism. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200002 |
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| Lavaee,Fatemeh; Moshaverinia,Maryam; MalekHosseini,Seyed Ali; Jamshidzade,Akram; Zarei,Maryam; Jafarian,Hadis; Haddadi,Pardis; Badiee,Parisa. |
| The aim of this study was to evaluate the antifungal susceptibility patterns of three antifungals, methanolic extracts and N-hexane oil of sesame seeds on C. albicans and C. glabrata, isolated from oral cavity of liver transplant recipients. The results were compared with other reports to develop a mini review as well. Candida species were isolated from liver transplant recipients. To evaluate the antifungal activity of sesame seed oil and methanolic extract, fluconazole, caspofungin and nystatin, the corresponding minimum inhibitory concentrations were determined by CLSI M27-A3 standard method. Minimum fungicidal concentration was also evaluated. The most prevalent species was C. albicans, followed by C. glabrata. Findings indicated sensitivity to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida species/ antifungal susceptibility; Sesame/study; Liver transplant. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100530 |
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| Lima,Rachel de; Brondani,Juliana Calil; Dornelles,Rafaela Castro; Lhamas,Cibele Lima; Faccin,Henrique; Silva,Carine Viana; Dalmora,Sérgio Luiz; Manfron,Melânia Palermo. |
| Verbena litoralis is a plant popularly known as “gervãozinho-do-campo” in Portuguese. It is traditionally used for stomach, liver and gallbladder problems, and as an anti-inflammatory and anthelmintic. The goal of this study was to determine the chemical composition of the crude extract obtained from the aerial parts of V. litoralis by Ultra High Performance Liquid chromatography coupled with Mass Spectrometry in Tandem (UHPLC-MS/MS); assess the anti-inflammatory activity of ethyl acetate fraction and of crude extract; and verify liver, kidney and pancreas damage. In this study, the chemical composition of the extract was identified via UHPLC/MS/MS, assessing the anti-inflammatory activity of the crude extract and the acetate fraction in an induction model... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Verbena litoralis; UHPLC/MS; Flavonoids; Anti-inflammatory. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100540 |
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| Rosa,Roseane Leandra da; Nardi,Geisson Marcos; Januário,Adriana Graziele de Farias; Boçois,Renata; Bagatini,Katiane Paula; Bonatto,Sandro José Ribeiro; Pinto,Andrea de Oliveira; Ferreira,João Ronaldo Notargiacomo; Mariano,Luisa Nathália Bolda; Niero,Rivaldo; Iagher,Fabíola. |
| Luehea divaricata (Malvaceae) is a plant widely used for treatment of various inflammatory and infectious conditions; however few reports discuss its biological properties. The aim of this study was to evaluate the anti-inflammatory and analgesic effects as well as the macrophage activity in mice treated with the hydroalcoholic crude extract of L. divaricata(CLD). Thin layer chromatography revealed presence of epicathequin, stigmasterol, lupeol and α,β-amyrin in the extract. To evaluate the anti-inflammatory and analgesic activities, animals were subjected to paw edema induced by carrageenan test, writhing, formalin and capsaicin tests. Immunomodulatory activity was evaluated by adhesion and phagocytic capacity, lysosomal volume, and reactive oxygen... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Luehea divaricata Mart. & Zucc./pharmacognosy Luehea divaricata Mart. & Zucc./hydroalcoholic crude extract/properties Anti-inflammatories Analgesics Reactive oxygen species. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300599 |
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| Vázquez,Ana Iris Frías; Sánchez,Carlos Manuel Dutok; Delgado,Neivys García; Alfonso,Ana María Suarez; Ortega,Yúlica Santos; Sánchez,Hiran Cabrera. |
| The aim of the present work was to investigate the anti-inflammatory and analgesic effects of red seaweed Dichotomaria obtusata, using classic tests in mice (ear edema induced by TPA and writhing induced by acetic acid). The qualitative chemical composition of the aqueous extract (lactones, phenols, triterpenes, steroids and reduced carbohydrates) obtained from this alga was also determined. The results showed that Dichotomaria obtusata (12.5, 25 and 50 mg/kg, ip) inhibited mouse ear edema in a dose-dependent manner. In the writhing test, aqueous extract (12.5, 25, 50 and 100 mg/kg, ip and 100, 200, 400, 800 mg/kg, po) significantly reduced abdominal writhes. In conclusion, this study demonstrated the anti-inflammatory and antinociceptive activities of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/analgesic activity; Mouse ear oedema test/Writhing test. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100014 |
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| García Delgado,Neivys; Frías Vázquez,Ana Iris; Cabrera Sánchez,Hiran; Soto del Valle,Roberto Menéndez; Sierra Gómez,Yusvel; Suárez Alfonso,Ana María. |
| The aim of the present work was to investigate the anti-inflammatory and antinociceptive effects of methanolic extract from D. obtusata using classic models in mice (croton oil-induced ear edema and acetic acid-induced writhing) and a phospholipase A2 activity test. Qualitative analysis of the chemical composition of seaweed was also determined by extraction with solvents of increasing polarity and precipitation and color tests. Results of qualitative chemical study showed the presence of lactonic and phenolic compounds, reduced carbohydrates, other sugars, flavonoids, fatty compounds, triterpenes and steroids. The extract inhibited mouse ear edema in a dose-dependent manner with an efficacy higher than 90% and a mean effective dose of 4.87µg/ear, while... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dichotomaria obtusata/pharmacognosy; Dichotomaria obtusata/anti-inflammatory activity; Dichotomaria obtusata/antinociceptive activity; Mouse ear edema test; Writhing test. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100008 |
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| Nascimento-Júnior,Braz José do; Brito,Lucas de Souza; Barros,Walquíria Nunes; Gonçalves,Daniela Marques; Matos,Luana de Souza; Nascimento,Cínthia Reyjane Borges; Ribeiro,Luciano Augusto de Araújo; Lima,Ricardo Santana de; Silva-Júnior,René Geraldo Cordeiro; Reis,Sílvio Alan Gonçalves Bomfim; Gonçalves,Talita Mota; Amorim,Elba Lúcia Cavalcanti de. |
| ABSTRACT The aim of this study was to investigate the effect of gels containing the monoterpene borneol in induced oral mucositis using an animal model. Gels were prepared with borneol at 1.2% and 2.4% (w/w). Oral mucositis was induced by administration of three doses of 5-fluorouracil (30 mg/kg, i.p.) and injury with acetic acid (50%, v/v) soaked in filter paper applied to right cheek mucosa for 60s. Four subgroups comprising 12 animals each were formed. Six animals from each group were sacrificed at days seven and fourteen after oral mucositis induction. Mucous samples were processed and stained with hematoxylin-eosin and Masson’s Trichrome. The semiquantitative evaluation involved observation of inflammatory parameters.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chemotherapy; Oral gel/Borneol monoterpene/effects; Oral gel/Borneol monoterpene/action anti-inflammatory; Oral gel/Borneol monoterpene/healing action; Bornyl alcohol/effects; Palliative care. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300604 |
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| Melo,Marcelia Garcez Dória de; Araújo,Adriano Antunes de Souza; Serafini,Mairim Russo; Carvalho,Larissa Feitosa; Bezerra,Marília Santos; Ramos,Cledison Santos; Bonjardim,Leonardo Rigoldi; Albuquerque-Júnior,Ricardo Luiz Cavalcanti; Lima,Julianeli Tolentino; Siqueira,Rosana Souza; Fortes,Vanessa Silveira; Fonseca,Maria José Vieira; Quintans-Júnior,Lucindo José. |
| Atranorin (ATR) is the main compound from the lichen Cladina kalbii Ahti, which grows in the arid regions of northeastern Brazil. This study was conducted to evaluate the anti-inflammatory and toxicological properties of ATR. To evaluate anti-inflammatory properties, paw edema was induced by injecting 0.1 mL of carrageenan into the subplantar region of the right hind paw of rats, and leukocyte migration was induced by injection of 500 µL of carrageenan into the peritoneal cavity of mice. In addition, we determined ATR cytotoxicity in L929 cells by MTT assay and acute (5 g/kg-single dose) and subchronic (50 mg/kg-30 days) toxicity tests in Wistar rats. The results showed that ATR (100 mg/kg and 200 mg/kg) exhibited significant anti-inflammatory activity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cladina kalbii/pharmacognosy; Atranorin/anti-inflamatory activity; Atranorin/toxicity; Medicinal plants. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400024 |
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| Ribeiro,Reginaldo Vicente; Silva,Regilane Matos da; Lima,Joaquim Corsino da Silva; Martins,Domingos Tabajara de Oliveira. |
| Macrosiphonia velame (Apocynaceae), popularly known as "velame-branco", is mainly used for treating inflammatory conditions. The antiinflammatory, antinociceptive and antipyretic effects of the hydroethanolic extract of the xylopodium from M. velame (HEMv) were evaluated using several animal models. HEMv showed low acute oral toxicity with LD50 of 4.176 ± 218.5 mg/kg in mice. In tests of carrageenan and dextran-induced paw edema and carrageenan-induced pleurisy in rats, and croton oil-induced cutaneous dermatitis in mice, HEMv presented systemic and topical antiinflammatory activities. In experiments of nociception induced by acetic acid, formalin and capsaicin in mice, the HEMv evidenced an antinociceptive effect, being active against both inflammatory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Macrosiphonia velame/antiinflammatory effect; Macrosiphonia velame/antinociceptive effect; Macrosiphonia velame/antipyretic effect; Macrosiphonia velame/pharmacognosy; Macrosiphonia velame/experimentel study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300015 |
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| Registros recuperados: 1.286 | |
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